Sustained Release of Naproxen in a New Kind Delivery System of Carbon Nanotubes Hydrogel

Peng, Xiahui; Zhuang, Qiang; Peng, Dongming; Dong, Qiuli; Tan, Lini; Jiao, Feipeng; Liu, Linqi; Liu, Jingyu; Zhao, Chenxi; Wang, Xiaomei

doi:10.22037/ijpr.2013.1390

Sustained Release of Naproxen in a New Kind Delivery System of Carbon Nanotubes Hydrogel

Document Type : Research article

Authors

¹ Department of Bioengineering and Environmental Science, Changsha University, Changsha 410003, China.

² School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

³ School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

10.22037/ijpr.2013.1390

Abstract

In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs-GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes.

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