Performance Evaluation of a Novel Potentiometric Membrane Sensor for Determination of Atorvastatin in Pharmaceutical Preparations

Document Type : Research article

Authors

1 1- Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran. 2-Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.

Abstract

A novel potentiometric ion-selective PVC membrane sensor for analysis of atorvastatin (AT) in
pharmaceutical preparations
based on atorvastatin-(tetraphenyl borate), (AT-(TPB)2) as sensing element, tetraphenyl borate as additive and tris-2-ethyl-hexyl phosphate (TOP) as plasticizer solvent was prepared. The electrode shows a good Nernestian response over the concentration range of 0.09–5586 µg mL-1of AT with slope of 30.1±0.1 mV/decade and limit of detection0.056µg mL-1.The response time of sensor is fats (less than 10 sec)and could be used for about one month in the pH range of 4.5–8.0. The electrode exhibit good selectivity for the AT in the presence of large amount of co-drugs and inorganic cations. The method is precise and accurate with mean relative standard deviation of <2%.Atorvastatin is determined successfully in several tablets by the proposed membrane.
 

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