The Genus Ferulago: A Review on Ethnopharmacology, Phytochemistry, and Pharmacology

Document Type : Review Paper


1 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

4 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

5 Department of Pharmacognosy, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.


The Ferulago genus appertains to the Umbelliferae family comprises 49 species which are mainly distributed in Asia, Europe, and Africa. This paper aims to review the morphological properties of Ferulago species, herbal components, and their pharmacological properties.
The information of this review paper has been collected from journals available in databases including Science Direct, Web of Science, Scopus, PubMed, EBSCO, Google Scholar, and Hindawi up to March 2020. In traditional medicine, the genus of Ferulago has been used to treat intestinal worms, snake bites, wound skin infections, diseases of the spleen and gastrointestinal tract, and headaches. It not only has been used traditionally as a preservative agent to dairy, oil ghee, and meat but also has given them a pleasant taste. The main components of Ferulago spp. are monoterpenes, sesquiterpenes, coumarin, furanocoumarin, flavonoids, and terpenoids have been the reason for the antimicrobial, antioxidant, anticoagulant, antidiabetic, Alzheimer, and larvicidal properties of this plant. This review confirms that many traditional uses of some Ferulago species have now been validated by modern pharmacology research. Rigorous investigations of all the species of Ferulago concerning phytochemical and pharmacological properties, mainly their mechanism of action, efficacy, and safety might offer a context for researchers to prosper plant-derived medications like anti-diabetes, antibiotics, and sedatives treating drugs, and the key to directing clinical trials.

Graphical Abstract

The Genus Ferulago: A Review on Ethnopharmacology, Phytochemistry, and Pharmacology


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