Almasirad, A., Samiee-Sadr, S., Shafiee, A. (2011). Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives. Iranian Journal of Pharmaceutical Research, Volume 10(4), 727-731. doi: 10.22037/ijpr.2011.984
Ali Almasirad; Somayeh Samiee-Sadr; Abbas Shafiee. "Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives". Iranian Journal of Pharmaceutical Research, Volume 10, 4, 2011, 727-731. doi: 10.22037/ijpr.2011.984
Almasirad, A., Samiee-Sadr, S., Shafiee, A. (2011). 'Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives', Iranian Journal of Pharmaceutical Research, Volume 10(4), pp. 727-731. doi: 10.22037/ijpr.2011.984
Almasirad, A., Samiee-Sadr, S., Shafiee, A. Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives. Iranian Journal of Pharmaceutical Research, 2011; Volume 10(4): 727-731. doi: 10.22037/ijpr.2011.984
Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
1Department of Medicinal Chemistry, Facalty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
2Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran, Iran.
Abstract
A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blue assay (MABA). Compounds 4f (5-Nitro-2-furyl analogue) and 4g (5-Nitro-2-thienyl analogue) showed antimycobacterial activity with IC90, 7.57 and 2.96 µg/mL, respectively.
Top