Shamsa, F., Foroumadi, A., Shamsa, H., Samadi, N., Faramarzi, M., Shafiee, A. (2011). Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones. Iranian Journal of Pharmaceutical Research, Volume 10(Number 2), 225-231.
Fazel Shamsa; Alireza Foroumadi; Hashim Shamsa; Nasrin Samadi; Mohammad Ali Faramarzi; Abbas Shafiee. "Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones". Iranian Journal of Pharmaceutical Research, Volume 10, Number 2, 2011, 225-231.
Shamsa, F., Foroumadi, A., Shamsa, H., Samadi, N., Faramarzi, M., Shafiee, A. (2011). 'Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones', Iranian Journal of Pharmaceutical Research, Volume 10(Number 2), pp. 225-231.
Shamsa, F., Foroumadi, A., Shamsa, H., Samadi, N., Faramarzi, M., Shafiee, A. Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones. Iranian Journal of Pharmaceutical Research, 2011; Volume 10(Number 2): 225-231.
Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones
1Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
3Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
4Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives showed better activity in comparison with mother drugs based on molar concentration; for example, the 3-acetyl phenanthrene analogue of norfloxacin was more effective than E. coli and K. pneumonia.
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