Antitumor Activity of Prosopis glandulosa Torr. on Ehrlich Ascites Carcinoma (EAC) Tumor Bearing Mice

Document Type : Research article

Authors

1 Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Tiruchengodu-637 205, Namakkal (Dt), Tamilnadu, India.

2 Department of Pharmacology, Dayanandha Sagar College of Pharmacy, Bangalore - 560 078, India.

3 Department of Pharmaceutical Chemistry, JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal Dt, Tamilnadu, India.

Abstract

The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantly (p < 0.001) increased the survival time and decreased the average body weight of the tumor bearing mice. After 14 days of inoculation, EPG was able to reverse the changes in the hematological parameters, protein and PCV consequent to tumor inoculation. Oral administration of EPG was effective in reducing solid tumor mass development induced by EAC cells. The results indicate that EPG possess significant antitumor activity on dose dependent manner.

Keywords

Iranian Journal of Pharmaceutical Research
Volume 10, Number 3
Summer 2011
Pages 505-510

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