An Approach to the Design of a Particulate System for Oral Protein Delivery .II. Preparation and Stability Study of rhGH-Loaded Microspheres in Simulated Gastrointestinal Fluids

Document Type: Research article

Authors

1 Department of Pharmaceutical Biotechnology, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

2 Department of Pharmaceutics, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

The delivery of therapeutic proteins has gained momentum with development of
biotechnology. However, large molecular weight, hydrophilic nature and susceptibility
to harsh environment of gastrointestinal tract (GIT) resulted in low absorption. The
main objective of this work was the design of a particulate system for oral delivery of
recombinant human growth hormone (rhGH) on the basis of particle uptake mechanism
in GIT. Biodegradable protein-loaded microspheres were prepared using Resomers
(RG207, RG756 and RG505) by double emulsion methods.

Keywords