Document Type: Research article
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shaheed Beheshti
University of Medical Sciences, Tehran, Iran.
Department of Pharmaceutics, School of
Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
The delivery of therapeutic proteins has gained momentum with development of
biotechnology. However, large molecular weight, hydrophilic nature and susceptibility
to harsh environment of gastrointestinal tract (GIT) resulted in low absorption. The
main objective of this work was the design of a particulate system for oral delivery of
recombinant human growth hormone (rhGH) on the basis of particle uptake mechanism
in GIT. Biodegradable protein-loaded microspheres were prepared using Resomers
(RG207, RG756 and RG505) by double emulsion methods.