Optimization of In-vitro Permeation Pattern of Ketorolac Tromethamine Transdermal Patches

Document Type: Research article

Authors

1 B.C. Roy College of Pharmacy and Allied Health Sciences, Bidhannagar, Durgapur, 713206, W.B. India.

2 School of Pharmaceutical Sciences, SOA University, Bhubaneswar-750030, Orissa, India

3 Department of Pharmaceutical Technology Jadavpur University, Kolkata-700032, India

4 B.C. Roy College of Pharmacy and Allied Health Sciences, Bidhannagar, Durgapur, 713206, W.B. India

5 College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India

Abstract

The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surface topography of the patches was examined by scanning electron microscopy (SEM). The drug-polymer interaction studies were performed using Fourier transform infrared spectroscopic (FTIR) technique. A correlation between in-vitro drug-release and in-vitro skin permeation was established and the criterion of desirability was employed to optimize the formulation. The results of the physicochemical characterization and in-vitro permeation of the prepared patches were promising to formulate transdermal patches with PVP/EC combinations.

Keywords