Ardeshiry lajimi, A., Rezaie-Tavirani, M., Mortazavi, S., Barzegar, M., Moghadamnia, S., Rezaee, M. (2010). Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321). Iranian Journal of Pharmaceutical Research, Volume 9(Number 4), 403-410.
Abdulreza Ardeshiry lajimi; Mostafa Rezaie-Tavirani; Seyed Alireza Mortazavi; Mansoureh Barzegar; Seyed Hasan Moghadamnia; Mohamad Bagher Rezaee. "Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321)". Iranian Journal of Pharmaceutical Research, Volume 9, Number 4, 2010, 403-410.
Ardeshiry lajimi, A., Rezaie-Tavirani, M., Mortazavi, S., Barzegar, M., Moghadamnia, S., Rezaee, M. (2010). 'Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321)', Iranian Journal of Pharmaceutical Research, Volume 9(Number 4), pp. 403-410.
Ardeshiry lajimi, A., Rezaie-Tavirani, M., Mortazavi, S., Barzegar, M., Moghadamnia, S., Rezaee, M. Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321). Iranian Journal of Pharmaceutical Research, 2010; Volume 9(Number 4): 403-410.
Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321)
1Proteomics Research Center (PRC), Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Department of Cell and Molecular Biology, Khatam Universiy, Tehran, Iran.
4Institute of Forest and Rangelands, Tehran, Iran.
Abstract
There are considerable efforts to identify naturally occurring substances as new drugs in cancer therapy. Many components of medicinal plants have been identified that possess substantial anticancerous properties. This prompted us to investigate the effect of Scrophularia striata (an Iranian species belonging to the Scrophulariace family) extract on the growth of astrocyte cancer cell line (1321). The 1321 cell line were seeded in 96-well culture plates in the presence and absence of various concentrations of either leaf and seed filtered and unfiltered extract of Scrophularia striata to determine their probable anticancer effects in comparison with etoposide (chemical anticancer reagent). filtered leaf extract of S. Striata showed strong anticancer effect on 1321cell line as compared to control group (cells not exposed to extracts), and even the group (adenocarcinoma gastric cell line) exposed to etoposide. Unlike the leaf extract, the seed extract activated cell proliferation in all experiments. Flow cytometry findings indicated that apoptosis is the mechanism by which the leaf extract inhibits cell proliferation. Our findings indicate that both leaves and seeds of S. Striata contain both anti cancer and cell growth enhancing agents.
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