Ahmadi, A., Hajikhani, R., Barghi, L., Mihandoust, F., Khalili, M. (2010). Synthesis and Determination of Chronic and Acute Thermal and
Chemical Pain Activities of a New Derivative of Phencyclidine in Rats. Iranian Journal of Pharmaceutical Research, Volume 9(Number 4), 379-385.
Abbas Ahmadi; Ramin Hajikhani; Leila Barghi; Farnaz Mihandoust; Mohsen Khalili. "Synthesis and Determination of Chronic and Acute Thermal and
Chemical Pain Activities of a New Derivative of Phencyclidine in Rats". Iranian Journal of Pharmaceutical Research, Volume 9, Number 4, 2010, 379-385.
Ahmadi, A., Hajikhani, R., Barghi, L., Mihandoust, F., Khalili, M. (2010). 'Synthesis and Determination of Chronic and Acute Thermal and
Chemical Pain Activities of a New Derivative of Phencyclidine in Rats', Iranian Journal of Pharmaceutical Research, Volume 9(Number 4), pp. 379-385.
Ahmadi, A., Hajikhani, R., Barghi, L., Mihandoust, F., Khalili, M. Synthesis and Determination of Chronic and Acute Thermal and
Chemical Pain Activities of a New Derivative of Phencyclidine in Rats. Iranian Journal of Pharmaceutical Research, 2010; Volume 9(Number 4): 379-385.
Synthesis and Determination of Chronic and Acute Thermal and
Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
1Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
2Department of Physiology, School of Medicine, Shahed University, Tehran, Iran.
Abstract
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP.
The results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following PCP-OCH3-tetralyl application in tail immersion test. However, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than PCP and PCP-OCH3-tetralyl exhibited almost similar analgesic effect.
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