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Ahmadi, A., Hajikhani, R., Barghi, L., Mihandoust, F., Khalili, M. (2010). Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats. Iranian Journal of Pharmaceutical Research, Volume 9(Number 4), 379-385. doi: 10.22037/ijpr.2010.903
Abbas Ahmadi; Ramin Hajikhani; Leila Barghi; Farnaz Mihandoust; Mohsen Khalili. "Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats". Iranian Journal of Pharmaceutical Research, Volume 9, Number 4, 2010, 379-385. doi: 10.22037/ijpr.2010.903
Ahmadi, A., Hajikhani, R., Barghi, L., Mihandoust, F., Khalili, M. (2010). 'Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats', Iranian Journal of Pharmaceutical Research, Volume 9(Number 4), pp. 379-385. doi: 10.22037/ijpr.2010.903
Ahmadi, A., Hajikhani, R., Barghi, L., Mihandoust, F., Khalili, M. Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats. Iranian Journal of Pharmaceutical Research, 2010; Volume 9(Number 4): 379-385. doi: 10.22037/ijpr.2010.903

Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats

Article 7, Volume 9, Number 4, Autumn 2010, Page 379-385  XML PDF (306.07 K)
Document Type: Research article
DOI: 10.22037/ijpr.2010.903
Authors
Abbas Ahmadi1; Ramin Hajikhani1; Leila Barghi1; Farnaz Mihandoust1; Mohsen Khalili2
1Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
2Department of Physiology, School of Medicine, Shahed University, Tehran, Iran.
Abstract
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP.
The results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following PCP-OCH3-tetralyl application in tail immersion test. However, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than PCP and PCP-OCH3-tetralyl exhibited almost similar analgesic effect.
Keywords
Phencyclidine; Ketamine, 1-Tetralone derivatives; Tail immersion test; Formalin test; Acute and chronic pain
Main Subjects
Medicinal chemistry; toxicology and Pharmacology
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