Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri

Document Type: Research article

Authors

Centre de Recherche et de Formation sur les Plantes Médicinales, Laboratoire de Physiologie Pharmacologie, Faculté Des Sciences, Université de Lomé, BP: 1515 Lomé, Togo.

Abstract

Aloe buettneri A. Berger is commonly used in traditional Togolese medicine to treat inflammatory and gastric ulcers. The present study examined the gastro-protection effect of the hydro-alcoholic extract of A. buettneri on mucus production and gastric pH. A gastric ulcer is induced by ethanol 95° alone (1 ml/kg body weight), after pre-treatment with indomethacin (300 mg/kg) or by utilising L-NAME (40 mg/kg IV). In addition gastric mucus was removed by scraping and subsequently weighed. The experiment focused entirely on rats that had been subjected to fasting. The hydro-alcoholic extract of A. buettneri (500 mg/kg) significantly inhibited ulcers that were induced by ethanol, indomethacin or L-NAME pre-treatment. A. buettneri was shown to increase the production of gastric mucus. Furthermore L-arginine significantly decreased the size of the induced ulcers. The results achieved in the study carried out suggest that A. buettneri posses gastro-protective properties.

Keywords

Iranian Journal of Pharmaceutical Research

Volume 10, Number 1
Winter 2011
Pages 69-74

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