Metowogo, K., Eklu-Gadegbeku, K., Agbonon, A., A. Aklikokou, K., Gbeassor, M. (2010). Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri. Iranian Journal of Pharmaceutical Research, Volume 10(Number 1), 69-74. doi: 10.22037/ijpr.2010.888
Kossi Metowogo; Kwashie Eklu-Gadegbeku; Amégnona Agbonon; Kodjo A. Aklikokou; Messanvi Gbeassor. "Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri". Iranian Journal of Pharmaceutical Research, Volume 10, Number 1, 2010, 69-74. doi: 10.22037/ijpr.2010.888
Metowogo, K., Eklu-Gadegbeku, K., Agbonon, A., A. Aklikokou, K., Gbeassor, M. (2010). 'Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri', Iranian Journal of Pharmaceutical Research, Volume 10(Number 1), pp. 69-74. doi: 10.22037/ijpr.2010.888
Metowogo, K., Eklu-Gadegbeku, K., Agbonon, A., A. Aklikokou, K., Gbeassor, M. Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri. Iranian Journal of Pharmaceutical Research, 2010; Volume 10(Number 1): 69-74. doi: 10.22037/ijpr.2010.888
Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri
Centre de Recherche et de Formation sur les Plantes Médicinales, Laboratoire de Physiologie Pharmacologie, Faculté Des Sciences, Université de Lomé, BP: 1515 Lomé, Togo.
Abstract
Aloe buettneri A. Berger is commonly used in traditional Togolese medicine to treat inflammatory and gastric ulcers. The present study examined the gastro-protection effect of the hydro-alcoholic extract of A. buettneri on mucus production and gastric pH. A gastric ulcer is induced by ethanol 95° alone (1 ml/kg body weight), after pre-treatment with indomethacin (300 mg/kg) or by utilising L-NAME (40 mg/kg IV). In addition gastric mucus was removed by scraping and subsequently weighed. The experiment focused entirely on rats that had been subjected to fasting. The hydro-alcoholic extract of A. buettneri (500 mg/kg) significantly inhibited ulcers that were induced by ethanol, indomethacin or L-NAME pre-treatment. A. buettneri was shown to increase the production of gastric mucus. Furthermore L-arginine significantly decreased the size of the induced ulcers. The results achieved in the study carried out suggest that A. buettneri posses gastro-protective properties.
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