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Ayatollahi, A., Ghanadian, M., Afsharypuor, S., Choudhary, M., Abdella, O., Shahlaei, M., Farzandi, G., Mostafavi, H. (2010). Cycloartanes from Euphorbia aellenii Rech. f. with Their Antiproliferative activity. Iranian Journal of Pharmaceutical Research, Volume 10(Number 1), 105-111. doi: 10.22037/ijpr.2010.882
Abdul Majid Ayatollahi; Mustafa Ghanadian; Suleiman Afsharypuor; Muhammad Iqbal Choudhary; Omer Mohamed Abdella; Mohsen Shahlaei; Gholamhossein Farzandi; Hamid Mostafavi. "Cycloartanes from Euphorbia aellenii Rech. f. with Their Antiproliferative activity". Iranian Journal of Pharmaceutical Research, Volume 10, Number 1, 2010, 105-111. doi: 10.22037/ijpr.2010.882
Ayatollahi, A., Ghanadian, M., Afsharypuor, S., Choudhary, M., Abdella, O., Shahlaei, M., Farzandi, G., Mostafavi, H. (2010). 'Cycloartanes from Euphorbia aellenii Rech. f. with Their Antiproliferative activity', Iranian Journal of Pharmaceutical Research, Volume 10(Number 1), pp. 105-111. doi: 10.22037/ijpr.2010.882
Ayatollahi, A., Ghanadian, M., Afsharypuor, S., Choudhary, M., Abdella, O., Shahlaei, M., Farzandi, G., Mostafavi, H. Cycloartanes from Euphorbia aellenii Rech. f. with Their Antiproliferative activity. Iranian Journal of Pharmaceutical Research, 2010; Volume 10(Number 1): 105-111. doi: 10.22037/ijpr.2010.882

Cycloartanes from Euphorbia aellenii Rech. f. with Their Antiproliferative activity

Article 15, Volume 10, Number 1, Winter 2011, Page 105-111  XML PDF (718.58 K)
Document Type: Research article
DOI: 10.22037/ijpr.2010.882
Authors
Abdul Majid Ayatollahi; Mustafa Ghanadian; Suleiman Afsharypuor; Muhammad Iqbal Choudhary; Omer Mohamed Abdella; Mohsen Shahlaei; Gholamhossein Farzandi; Hamid Mostafavi
School of Pharmacy and Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes — cycloart-25-en-3,24-diol (1) and 24-methylene-cycloartan-3-ol (2) — for the first time from this plant. Preparation of cycloartane derivatives, 3, 24-O-diacetyl-cycloart-25-en as compound 3 and 3-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluated by proliferation assay on Human peripheral blood lymphocytes (PBLs). Comparing the results suggested that anti-proliferation effect of these compounds on PBLs might be due to the presence of free 3-OH group while masking the free OH groups by acetylation, could induce proliferation activity.
Keywords
Euphorbia aellenii; Proliferation assay; cycloartanes; SAR, structure–activity relationship; PKC, Protein kinase C
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