• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Iranian Journal of Pharmaceutical Research
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 18 (2019)
Volume Volume 17 (2018)
Volume Volume 16 (2017)
Volume Volume 15 (2016)
Volume Volume 14 (2015)
Volume Volume 13 (2014)
Volume Volume 12 (2013)
Volume Volume 11 (2012)
Volume Volume 10 (2011)
Volume Volume 9 (2010)
Volume Volume 8 (2009)
Volume Volume 7 (2008)
Volume Volume 6 (2007)
Volume Volume 5 (2006)
Volume Volume 4 (2005)
Volume Volume 3 (2004)
Issue Supplement 2
Issue Supplement 1
Issue Number 4
Issue Number 3
Issue Number 2
Issue Number 1
Volume Volume 2 (2003)
Volume Volume 1 (2002)
Sara, S. (2010). Early and late consolidation and reconsolidation of memory in the prelimbic cortex. Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 1), 5-5. doi: 10.22037/ijpr.2010.75
SJ Sara. "Early and late consolidation and reconsolidation of memory in the prelimbic cortex". Iranian Journal of Pharmaceutical Research, Volume 3, Supplement 1, 2010, 5-5. doi: 10.22037/ijpr.2010.75
Sara, S. (2010). 'Early and late consolidation and reconsolidation of memory in the prelimbic cortex', Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 1), pp. 5-5. doi: 10.22037/ijpr.2010.75
Sara, S. Early and late consolidation and reconsolidation of memory in the prelimbic cortex. Iranian Journal of Pharmaceutical Research, 2010; Volume 3(Supplement 1): 5-5. doi: 10.22037/ijpr.2010.75

Early and late consolidation and reconsolidation of memory in the prelimbic cortex

Article 9, Volume 3, Supplement 1, Autumn 2004, Page 5-5  XML
DOI: 10.22037/ijpr.2010.75
Author
SJ Sara
Abstract
Rats can learn to forage among olfactory cues to associate one with reward in only 3 massed trials. The learning is achieved in less than 10 min and results in a memory trace lasting at least 1wk week. To study the neuro-anatomical circuits involved in the memory formation we used immunoreactivity to the immediate early gene c-fos as a marker for neuronal activity induced by the learning. The prelimbic cortex (PLC) was one of the few regions showing selective increases in c-fos immunoreactivity in trained rats compared to yoked pseudo-trained. In subsequent experiments, injection of an NMDA receptor antagonist directly into PLC immediately after learning induced amnesia 48h later, while similar injections into the hippocampus had no effect. Injections of the beta-adrenergic antagonist, timolol, 2h, but not 5 min after training also produced amnesia. This suggests that PLC is part of a neural circuit activated for an extended period during the post-acquisition consolidation of memory for odor-reward association. We studied reconsolidation processes after reactivation and found that injections of the NMDA receptor antagonist or the beta antagonist could block reconsolidation with similar temporal dynamics as during consolidation when the injections were made into the lateral ventricles, but not into the PLC. Thus, similar cellular mechanisms but different neural circuits appear to be involved in initial consolidation and reconsolidation.
Statistics
Article View: 3,363
PDF Download: 11
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Statistics

Journal Management System. Designed by sinaweb.