Antifungal activity of Peganum harmala seeds extract in vitro

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Abstract

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro.
Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton tonsurans and Fonsecaea pedrosoi.
P. harmala extract, diluted 2.5:1000, produced complete inhibition against microsporum and trichophyton species. The extract had a considerable antifungal activity. Further purification and extraction of the active principles (alkaloids) of P. harmala seeds might show a true antifungal activity comparable to standard antifungal drugs.

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Iranian Journal of Pharmaceutical Research (2004): Supplement 2

Iranian Journal of Pharmaceutical Research (2004): Supplement 2: 79-79
Poster Presentations/Biological Effect of Medicinal Plants

2nd International Congress on Traditional Medicine and Materia Medica
October 4-7, 2004, Tehran, Iran

237

Antifungal activity of Peganum harmala seeds extract in vitro

Shafiei M.1, Kayhani M.2, Nikpay H-R.3, Mostafaei-Rad P.1

1Razi Institute of Drug Research, 2Department of Biochemistry, 3Department of Parasitology and Mycology, Iran University Med. Sci., Tehran, Iran

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro.

Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton tonsurans and Fonsecaea pedrosoi.

P. harmala extract, diluted 2.5:1000, produced complete inhibition against microsporum and trichophyton species. The extract had a considerable antifungal activity. Further purification and extraction of the active principles (alkaloids) of P. harmala seeds might show a true antifungal activity comparable to standard antifungal drugs.

Presenting Author: Shafiei, M. mshafiei@iums.ac.ir

Iranian Journal of Pharmaceutical Research

Volume 3, Supplement 2
Autumn 2004
Pages 79-79

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