Moradi, F., Lotfi Maldar, F., Saeidnia, S., Gohari, A. (2010). Investigation of cytotoxic activity for Achillea talagonica and A. tenuifolia. Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), 76-76.
F Moradi; F Lotfi Maldar; S Saeidnia; AR Gohari. "Investigation of cytotoxic activity for Achillea talagonica and A. tenuifolia". Iranian Journal of Pharmaceutical Research, Volume 3, Supplement 2, 2010, 76-76.
Moradi, F., Lotfi Maldar, F., Saeidnia, S., Gohari, A. (2010). 'Investigation of cytotoxic activity for Achillea talagonica and A. tenuifolia', Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), pp. 76-76.
Moradi, F., Lotfi Maldar, F., Saeidnia, S., Gohari, A. Investigation of cytotoxic activity for Achillea talagonica and A. tenuifolia. Iranian Journal of Pharmaceutical Research, 2010; Volume 3(Supplement 2): 76-76.
Investigation of cytotoxic activity for Achillea talagonica and A. tenuifolia
Achillea (Asteraceae) comprises 115 species, which are mainly distributed in Europe, Asia, and North Africa and as an introduced plant in the New World. The genus Achillea, generally called Bumadaran in Persian, is well known for medicinal properties such as anthelmintic, anti-inflammatory and anti-microbial effects. Achillea has long been used in traditional medicine for treatment of neuralgia and rheumatic pain. Achillea talagonica and Achillea tenuifolia are two of nineteen herbaceous species growing in north of Iran. In previous studies, A. talagonica showed the strongest in vivo immunosuppressive activity and A. tenuifolia had an antimicrobial effect.
In this study, we examined the cytotoxic activity of the ethyl acetate, methanol and aqueous methanol extracts of these two species by Brine Shrimp Cytotoxicity Assay, which is a well-known screening method for finding the active natural products using Artemia Salina eggs.
The results show that all extracts from both plants have a good cytotoxic effect against the larve of A. salina. The minimum lethal concentration of aqueous methanolic extract of A. tenuifolia is 250 µg/ml. The effective concentration of the methanolic extract of A. talagonica is more than 100 µg/ml. Thus, Ethyl acetate extract of A. tenuifolia is more effective than A. talagonica.
Finally, Achillea talagonica and A. tenuifolia are two effective plants on the larve of A. salina. Different polarity extracts of both species showed cytotoxic activity.
Full Text
Iranian Journal of Pharmaceutical Research (2004): Supplement 2
Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
76-77
Poster Presentations/Biological Effect of
Medicinal Plants
2nd International Congress on Traditional Medicine and Materia Medica October 4-7, 2004, Tehran, Iran
229
Investigation of
cytotoxic activity for Achillea talagonica and A. tenuifolia
Department of
Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences,
Sari, Iran
Achillea (Asteraceae) comprises 115 species, which are mainly distributed in
Europe, Asia, and North Africa and as an introduced plant in the New World. The
genus Achillea, generally called Bumadaran in Persian, is well known for
medicinal properties such as anthelmintic, anti-inflammatory and anti-microbial
effects. Achillea has long been used in traditional medicine for treatment of
neuralgia and rheumatic pain. Achillea talagonica and Achillea tenuifolia
are two of nineteen herbaceous species growing in north of Iran. In previous
studies, A. talagonica showed the strongest in vivo immunosuppressive
activity and A. tenuifolia had an antimicrobial effect.
In
this study, we examined the cytotoxic activity of the ethyl acetate, methanol
and aqueous methanol extracts of these two species by Brine Shrimp Cytotoxicity
Assay, which is a well-known screening method for finding the active natural
products using Artemia Salina eggs.
The results show that all extracts from both plants have a good cytotoxic effect
against the larve of A. salina. The minimum lethal concentration of aqueous
methanolic extract of A. tenuifolia is 250 µg/ml. The effective
concentration of the methanolic extract of A. talagonica is more than 100 µg/ml.
Thus, Ethyl acetate extract of A. tenuifolia is more effective than A.
talagonica.
Finally, Achillea talagonica and A. tenuifolia are two effective
plants on the larve of A. salina. Different polarity extracts of both species
showed cytotoxic activity.
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