Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
The evaluation of cytotoxicity of suab1 on l929 fibroblast cell line and the comparison with formocresol
Mehran M., Ghazanfari T., Naseri M., Esmaili Z.
Shahed dental faculty, Tehran, Iran
Formocresol is common treatment in exposed pulp of primary teeth at caries, trauma and damaged with cavity preparation. Although, clinical and radiographic success and good clinical results are observed, dentistry societies are still searching for materials interchangeable with formocresol. Suab1 is a phytochemical agent that was selected because of its anti- bleeding effect. In this study, we evaluated cytotoxicity of SUAB1 in comparison with formocresol on L929 fibroblast cell line.
Cytotoxicity evaluation performed with Crystal Violet Assey (ELISA), microscopic observation and optical counting. Results were calculated with Excel® software. Analysis of variance and t-test were used for statistical inference; p<0.05 was considered statistically significant.
Results showed that cytotoxicity of SUAB1 is lower than formocresol. SUAB1 appears as a good substitute candidate of formocresol in pediatric dentistry.