An alarming biochemical side effect of Teucrium polium on the plasma membrane alkaline phosphatase of k562 cell line

Authors

Abstract

The unexpected enhancement of alkalinee phosphatase (ALP) activity in the serum of a group of STZ-diabetic rats recieving the Teucrium polium extract (with hypoglycaemic property) may be attributed to its probable side effects. In order to get a more precise knowledge about this subject, we evaluated the effect of T. polium extract on the plasma membrane ALP activity of K562 cell line.
Our data indicated that upon treatment of cells with a single effective dose of T. polium extract, the ALP activity in the cultured medium increased by 20%, while the matching activity in the plasma membrane of the same cell decreased 20%.
These observations clearly indicate that T. polim is capable of damaging the plasma membrane by enhancing the solubilization of one of its major components, ALP. Regarding the medical significance of ALP and these data the pharmaceutical consumption of T. polium extract, as a hypoglycaemic aid, should be carefully supervised by medical personals

Iranian Journal of Pharmaceutical Research (2004): Supplement 2

Iranian Journal of Pharmaceutical Research (2004): Supplement 2: 72-72
Poster Presentations
/Biological Effect of Medicinal Plants

2nd International Congress on Traditional Medicine and Materia Medica
October 4-7, 2004, Tehran, Iran

214

An alarming biochemical side effect of Teucrium polium on the plasma membrane alkaline phosphatase of k562 cell line

Esmaeili M.A., Yazdanparast R.

Institute of Biochemistry and Biophysics University of Tehran, Tehran, Iran

The unexpected enhancement of alkalinee phosphatase (ALP) activity in the serum of a group of STZ-diabetic rats recieving the Teucrium polium extract (with hypoglycaemic property) may be attributed to its probable side effects. In order to get a more precise knowledge about this subject, we evaluated the effect of T. polium extract on the plasma membrane ALP activity of K562 cell line.

Our data indicated that upon treatment of cells with a single effective dose of T. polium extract, the ALP activity in the cultured medium increased by 20%, while the matching activity in the plasma membrane of the same cell decreased 20%.

These observations clearly indicate that T. polim is capable of damaging the plasma membrane by enhancing the solubilization of one of its major components, ALP. Regarding the medical significance of ALP and these data the pharmaceutical consumption of T. polium extract, as a hypoglycaemic aid, should be carefully supervised by medical personals

Presenting Author: Esmaeili, M.A. esmaeli@ibb.ut.ac.ir