Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Analgesic effects of aqueous extract of Teucrium polium L. in experimental models of pain in male rats
Verdi J.1, Komeilizadeh H.2, Kamalinejad M.2, Sharif Sh.1
1Department of Pharmacology, Shaheed Beheshti University 2School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
There are some reports in ancient medicinal literature that aqueous extracts of the leaves of Teucrium polium show analgesic effects.
This prompted us to investigate the analgesic effect of the leaves of the plant using Tail-Flick and Fomalin tests.
For this purpose, male NMRI rats weighing 220-260 g were used in all experiments.
The aqueous extract of the plant was injected intraperitoneally at doses of 150, 200 and 400 mg/kg. In this study, sodium salicylate (100 and 300 mg/kg) and distilled water were used as positive and negative controls, respectively. The results obtained were analyzed using one-way ANOVA and Tukey-Kramer tests.
Our data showed that intraperitoneal injection of aqueous extract of leaves of this plant (150, 200 and 400 mg/kg) produces significant analgesia in both phases of the formalin test (P<0.001). Meanwhile, different doses of this plant did not produce any analgesic effect in tail-flick and hot plate tests.
On the other hand, sodium salicylate (100 and 300 mg/kg) induced analgesia in second phase of formalin test.
Aqueous leaf extract of Teucrium polium L. showed analgesic effects in both phases of formalin test. Therefore, it may be concluded that the extract produces anti-nociception through the central mechanisms. In this respect, flavonoid and steroid compounds of the plant may be involved in the anti-nociceptive effects in rats.