Assessment of hydroalcoholic extract of Foeniculum vulgare on acute pain in hot plate and tail flick in mice

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Abstract

Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models.
Albino mice (20-30 gr) were used for this study. Hydroalcoholic extract of FV seed was injected in doses of 200 and 500 mg/kg 30 min before test. Then the analgesic effect of the drug on acute pain was evaluated using Hot plate and Tail flick models
Results indicated that FV has analgesic effect in both doses in both models (P<0.01).
Finding above showed that FV can modulate acute pain. Further research is required to determine the mechanisms by which FV has an inhibitory effect on pain sensation.

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Iranian Journal of Pharmaceutical Research (2004): Supplement 2

Iranian Journal of Pharmaceutical Research (2004): Supplement 2: 61-61
Poster Presentations/Ethnopharmacology

2nd International Congress on Traditional Medicine and Materia Medica
October 4-7, 2004, Tehran, Iran

182

Assessment of hydroalcoholic extract of Foeniculum vulgare on acute pain in hot plate and tail flick in mice

Taherian A.A., Vafaei A.A., Rashidy-Pour A., Sadeghi H.

Department of Physiology and Pharmacology, Faculty of Medicine, University of Medical Sciences, Semnan, Iran

Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models.

Albino mice (20-30 gr) were used for this study. Hydroalcoholic extract of FV seed was injected in doses of 200 and 500 mg/kg 30 min before test. Then the analgesic effect of the drug on acute pain was evaluated using Hot plate and Tail flick models

Results indicated that FV has analgesic effect in both doses in both models (P<0.01).

Finding above showed that FV can modulate acute pain. Further research is required to determine the mechanisms by which FV has an inhibitory effect on pain sensation.

Presenting Author: Taherian, A. aavaf43@yahoo.com

Iranian Journal of Pharmaceutical Research
Volume 3, Supplement 2
Autumn 2004
Pages 61-61

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