Assessment of hydroalcoholic extrac of Carum carvi on acute pain in hot plate and tail flick in mice

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Assessment of hydroalcoholic extrac of Carum Carvi on acute pain in hot plate and tail flick in mice

Taherian A.A., Vafaei A.A., Rashidy-Pour A., Sadeghi H.

Department of Physiology and Pharmacology, Faculty of Medicine, University of Medical Sciences, Semnan, Iran

Since use of antinoceceptive chemical drugs for relief of pain has many side effects, medical plants seem very noticeable today. Previous findings indicate that Carum Carvi (CC) modulates pain in both animal and human. The present work investigated the effects of hydoalcoholic extract of CC on acute pain in Hot plate and Tail flick models.

Albino mice (20-30 g) were used for this study. Hydroalcoholic extract of CC seed was injected in doses of 100 and 500 mg/kg 30 min before test. Then the analgesic effect of the drug on acute pain was evaluated using Hot plate and Tail flick models.

Results indicated that CC has analgesic effect in both doses in both models and higher dose of the drug was more effective (P<0.01).

The above findings show that CC can modulate acute pain. Further research is required to determine the mechanisms by which CC has an inhibitory effect on pain sensation.