Immunological effects of Teucrium polium on neutrophils

Authors

Abstract

Teucrium polium, a medicinal plant that belongs to the family Labiatae is widely used in folk medicine as antidiabetic, antibactrial and anti-inflammatory agent. In this study, we evaluated the effect of Teucrium polium on the mouse polymorphonuclear neutrophils.
The animals were divided into five groups including four test and one control group, which orally received 50 and 100 mg/kg of aqueous and alcoholic extract of the plant and saline (in controls) respectively. Respiratory burst of the peritoneal neutrophils were evaluated after 10 days by chemiluminescenece assay using PMA as stimulator of oxidative burst.
The results showed that alcoholic and aqueous extracts of the plant are effective in augmentation of neutrophil activity but this effect was statistically significant only for aqueous extract in 100 mg/kg.
Results of this study showed that the anti-inflammatory effect of the plant may result partly from improvement in neutrophils function.

Iranian Journal of Pharmaceutical Research (2004): Supplement 2

Iranian Journal of Pharmaceutical Research (2004): Supplement 2: 61-61
Poster Presentations/Ethnopharmacology

2nd International Congress on Traditional Medicine and Materia Medica
October 4-7, 2004, Tehran, Iran

179

Immunological effects of Teucrium polium on neutrophils

Sharifian Z., Vodgani M., Hajati pour J., Kamalinejad M.

Immounology Department, Medical Faculty, Tehran, Iran

Teucrium polium, a medicinal plant that belongs to the family Labiatae is widely used in folk medicine as antidiabetic, antibactrial and anti-inflammatory agent. In this study, we evaluated the effect of Teucrium polium on the mouse polymorphonuclear neutrophils.

The animals were divided into five groups including four test and one control group, which orally received 50 and 100 mg/kg of aqueous and alcoholic extract of the plant and saline (in controls) respectively. Respiratory burst of the peritoneal neutrophils were evaluated after 10 days by chemiluminescenece assay using PMA as stimulator of oxidative burst.

The results showed that alcoholic and aqueous extracts of the plant are effective in augmentation of neutrophil activity but this effect was statistically significant only for aqueous extract in 100 mg/kg.

Results of this study showed that the anti-inflammatory effect of the plant may result partly from improvement in neutrophils function.

Presenting Author: Sharifian, Z. sharifian72@yahoo.com