Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Assessment of extract of Carum Carvi on acute and chronic pain in mice in formalin test in mice
Taherian A.A., Rashidy-Pour A., Vafaei A.A., Sadeghi H.
Department of Physiology and Pharmacology, Faculty of Medicine, University of Medical Sciences, Semnan, Iran
Few previous investigations show that Carum Carvi (CC) may control pain in both animal and human. The aim of this work was to assess the role of CC on acute and chronic pain in formalin test in mice.
In this study male albino mice (25-30 g) were used. CC (100 and 500 mg/kg) and saline were injected 30 min before formalin test. Indexes of signs were licking and foot elavation for assessment of acute pain (5 min) and chronic pain (15-40 min) after injection of formalin 5% (25 µl) in right paw.
Results indicated that CC has analgesic effect pain in both doses in acute and chronic phases and higher dose of the drug was more effective (P<0.01).
Above findings show that CC can attenuate acute and chronic pain in formalin test. Further research is required to determine the mechanisms by which CC has an inhibitory effect on pain sensation.