Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Green tea extract formulation may promote wound healing
Moghbel A., Hemmati A.A., Agheli H., Aghel N., Rahimzadeh F., Kavand M.
The School of pharmacy, Jundishapur University of Medical Sciences, Ahwaz, Iran
Wound repair is a natural reaction to injury, which results in restoration of tissue integrity. In this study the healing effect of green tea extract formulation was investigated on open skin wound of rabbit.
Active ingredients were extracted from green tea using water and glycerin (4:1) vehicle. Three cream formulations containing 2, 5 and 10% of green tea extract were prepared in the base. A full tickness wound was made on the left flank rabbits. Green tea creams were applied on wound area twice daily. Control groups were treated with the base only or phenytoin cream 1%. Healing was determined quantitatively as the reduction in wound area.
The wound healing profile of green tea treated groups were significantly better than non-treated groups. The best healing effect was observed in the green tea cream, which exert the lowest period for healing. Such effect was significantly different from phenytoin or the base. The quantity of tissue repairing was confirmed by histological examination.
Green tea formulation exhibited a considerable potency for wound healing (P<0.05). This is probably due to acceleration of collagenation and proliferation phases of wound repair