Comparison between hypoglycemic effects of Cuminum cyminum L. seeds and glibenclamide in diabetic rats

Authors

Abstract

The purpose of this research was to compare the anti-hyperglycemic effect of Cuminum cyminum L. and glibenclamide, a known antidiabetic drug, in diabetic rats.
After collection and taxonomic identification of plant, alcoholic extract of seeds prepared suxhlet apparatus respectively. The animals were made diabetic by using streptozotocin (70 mg/kg, i.p.). The diabetic rats were administrated intraperitoneally with the extract or glibenclamide (600 mg/kg). Blood samples were obtained before administration and 1.5, 3 and 5 h after administration of extract and distilled water as a control groups. Then, the blood glucose was measured by the enzymatic method of glucose oxidize.
The results show that the antidiabetic effect of Cuminum cyminum was more effective than glibenclamide.
It is concluded that this plant must be considered as an excellent candidate for future studies on diabetes mellitus. In addition, further comprehensive pharmacological investigations, including experimental chronic studies, should be carried out.

Iranian Journal of Pharmaceutical Research (2004): Supplement 2

Iranian Journal of Pharmaceutical Research (2004): Supplement 2: 56-56
Poster Presentations
/Ethnopharmacology

2nd International Congress on Traditional Medicine and Materia Medica
October 4-7, 2004, Tehran, Iran

165

Comparison between hypoglycemic effects of Cuminum cyminum L. seeds and glibenclamide in diabetic rats

Eidi A.1, Eidi M.2, Oryan S.3, Maghsoudi D.1, Ghoushchi F.2

1Science and Research Unit, Azad Islamic University, Tehran 2Science Faculty, Varamine Unit, Azad Islamic University 3Department of Biology, Faculty of Science, Teacher Training University, Tehran

The purpose of this research was to compare the anti-hyperglycemic effect of Cuminum cyminum L. and glibenclamide, a known antidiabetic drug, in diabetic rats.

After collection and taxonomic identification of plant, alcoholic extract of seeds prepared suxhlet apparatus respectively. The animals were made diabetic by using streptozotocin (70 mg/kg, i.p.). The diabetic rats were administrated intraperitoneally with the extract or glibenclamide (600 mg/kg). Blood samples were obtained before administration and 1.5, 3 and 5 h after administration of extract and distilled water as a control groups. Then, the blood glucose was measured by the enzymatic method of glucose oxidize.

The results show that the antidiabetic effect of Cuminum cyminum was more effective than glibenclamide.

It is concluded that this plant must be considered as an excellent candidate for future studies on diabetes mellitus. In addition, further comprehensive pharmacological investigations, including experimental chronic studies, should be carried out.

Presenting Author: Maghsoudi, D. akram_eidi@yahoo.com