Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Anti-inflammatory activity of aerial part of Stachys byzanthina C.Koch.
Khanavi M.1, Sharifzadeh M.2, Hadjiakhoondi A.1, Shafiee A.3
1Department of Phamacognosy and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 2Department of Toxicology and Pharmacology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences 3Department of Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Anti-inflammatory effects of acetonic and methanolic extracts of aerial parts of Stachys byzanthina were investigated in this study.
For assessment of anti-inflammatory properties, two well-characterized inflammatory models, formalin test and carrageenan-induced paw edema were used. In the former, the recording of the early phase started immediately after formalin injection and lasted for 10 min (0-10 min) and the late response was recorded 20 min after formalin injection and lasted for 10 min (20-30 min).
Interaperitoneal injections of either acetonic or methanolic extract of S. byzanthina (50, 100, 200 mg/kg), 30 min before formalin injection, had no effects against the first phase of the formalin- induced pain, but all three doses caused a significant blockade on the second phase (P<0.01). In the carrageenan-induced paw edema, both extracts revealed dose-related inhibitory effects on carrageenan-induced rat paw edema over the dose range 50-200 mg/kg. The anti-inflammatory activities of these extracts were similar to high dose of indomethacin (5 mg/kg) in both carrageenan-induced paw edema and formalin-induced paw licking.
The present data provide further evidence for an important role of extracts of Stachys byzanthina in the inhibition of pain and inflammatory processes.