Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Analgesic effect of aqueous leaf extract of Coriandrum sativum in male streptozotocin-diabetic rats
Khalili M., Atyabi M.
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
Hyperalgesia is one of the symptoms of the diabetic neuropathy, is considered as a major clinical complaint in these patients, and could affect the quality of their living style. Since attenuation of hyperalgesia is very important, in the present study the possible analgesic effect of aqueous extract of coriander was investigated in male streptozotocin-diabetic rats using standard formalin test in both early (acute) and late (chronic) phases.
In this research study, male albino Wistar rats (250-350 g) were used. They were randomly divided into three groups, i.e. control, diabetic and extract-treated diabetic. For induction of diabetes, streptozotocin (60 mg/Kg) was administered i.p. After one month, formalin test was conducted.
The obtained findings demonstrated that pain sensation in the second interval (5-10 min) of the acute phase of the formalin test is higher (P<0.001) in comparison with control group, while a less significant difference was found out between control and extract-treated diabetic group (P<0.05). On the other hand, there was no significant difference
In addition, the present study showed that the acute formalin pain was augmented due to diabetes mellitus, and this hyperalgesic production was not changed by the aqueous leaf extract of Coriandrum sativum.