Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Anti-inflammatory activity of Asparagus racemosus and its in-vitro cultures
Asmari S., Zafar R., Ahmad S., Mojeeb M.
Plant Tissue Culture Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
To determine the pharmacological (Anti-inflammatory) potential of in-vitro cultures of Asparagus racemosus.
Anti-inflammatory activity of methanolic extracts of shoot, root their calli and genetically transformed shoot culture was performed using carrageenan induced rat paw edema method. The albino rats were treated orally with two dosage (500 or 1000 mg/kg body weight of rats) of drugs, one hour prior to injection of carrageenan (0.1 ml, 1%, i.p.) in right hind paw. The paw volume was measured just before and upto 3 hour after the injection of carrageenan.
Methanolic extract of root (1000 mg/kg body weight) showed best result (81.81% inhibition) followed by root callus extract.
The natural root extract showed significant anti-inflammatory activity whereas in cultured cells only root callus extract (500 mg/kg body weight) was found to give better result.