Ahmad, N., Tajuddin, , Maheshwari, V., Zaidi, S., Nasiruddin, M. (2010). Cardioprotective potential of hydro-alcoholic extract of Nepeta hindostana (roth) on isoproternol induced myocardial Infarction in rats. Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), 50-50.
N Ahmad; Tajuddin; V Maheshwari; S Zaidi; M Nasiruddin. "Cardioprotective potential of hydro-alcoholic extract of Nepeta hindostana (roth) on isoproternol induced myocardial Infarction in rats". Iranian Journal of Pharmaceutical Research, Volume 3, Supplement 2, 2010, 50-50.
Ahmad, N., Tajuddin, , Maheshwari, V., Zaidi, S., Nasiruddin, M. (2010). 'Cardioprotective potential of hydro-alcoholic extract of Nepeta hindostana (roth) on isoproternol induced myocardial Infarction in rats', Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), pp. 50-50.
Ahmad, N., Tajuddin, , Maheshwari, V., Zaidi, S., Nasiruddin, M. Cardioprotective potential of hydro-alcoholic extract of Nepeta hindostana (roth) on isoproternol induced myocardial Infarction in rats. Iranian Journal of Pharmaceutical Research, 2010; Volume 3(Supplement 2): 50-50.
Cardioprotective potential of hydro-alcoholic extract of Nepeta hindostana (roth) on isoproternol induced myocardial Infarction in rats
The present study evaluated cardioprotective effect of hydro-alcoholic extract of Nepeta hindostana (NH), commonly know as badranjbuyeh in Unani medicine, in the experimental model of isoproterenol (ISO) induced- myocardial infarction.
Wistar albino rats were divided in to four groups: sham control, ISO control, NH treatment group and ISO with NH treatment groups. NH was administered at doses of 25, 50 and 100 mg / 100 gm b w, orally for sixty days. On days 59th and 60th the rats of ISO control and NH treatment groups were administered ISO (20 mg / 100 mg b w) subcutaneously twice at an interval of 24 hrs. On 61 st the rats were sacrificed and serum was separated for biochemical parameters, creatinine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and lipid peroxide level and heart was processed for histopathalogical studies.
The result suggests a promising cardioprotective role of NH treatment on isoproterenol-administered myocardial damage, which is probably mediated through NH antioxidant effects and contributing to prevention of acute myocardial infarction in rats.
Full Text
Iranian Journal of Pharmaceutical Research (2004): Supplement 2
Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
50-50
Poster Presentations/Ethnopharmacology
2nd International Congress on Traditional Medicine and Materia Medica October 4-7, 2004, Tehran, Iran
143
Cardioprotective
potential of hydro-alcoholic extract of Nepeta hindostana (roth) on
isoproternol induced myocardial Infarction in rats
Ahmad N., Tajuddin,
Maheshwari V., Zaidi S., Nasiruddin M.
Depts.of llmu
Advia, Faculty of Unani medicine and Medical College, Aligarh Muslim University,
Aligarh, India
The present study evaluated cardioprotective effect of hydro-alcoholic extract
of Nepeta hindostana (NH), commonly know as badranjbuyeh in Unani
medicine, in the experimental model of isoproterenol (ISO) induced- myocardial
infarction.
Wistar albino rats were divided in to four groups: sham control, ISO control, NH
treatment group and ISO with NH treatment groups. NH was administered at doses
of 25, 50 and 100 mg / 100 gm b w, orally for sixty days. On days 59th and 60th
the rats of ISO control and NH treatment groups were administered ISO (20 mg /
100 mg b w) subcutaneously twice at an interval of 24 hrs. On 61 st the rats
were sacrificed and serum was separated for biochemical parameters, creatinine
phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase (AST),
alanine transaminase (ALT) and lipid peroxide level and heart was processed for
histopathalogical studies.
The result suggests a promising cardioprotective role of NH treatment on
isoproterenol-administered myocardial damage, which is probably mediated through
NH antioxidant effects and contributing to prevention of acute myocardial
infarction in rats.
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