Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Anti-inflammatory effects of Urtica pilulifera l. seeds extracts in the rat
Abbasian A.1, Naseri M.2, Masoud A.3
1Scientific Research Center, Tehran University of Medical Sciences, 2Department of Pharmacology, School of Medicine, Shahed University, 3Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
Urtica pilulifera l. seeds extracts (Decocted and Methanolic extracts) have anti-inflammatory effects.
In an experimental-interventional study, Anti-inflammatory effects of Urtica pilulifera l. (UPL), a Traditional Iranian Medicine (TIM) plant, were examined with formalin-induced hind paw edema model in the rat. Sodium salicylate (S.S) injection (300 mg/kg; IP) was used as a positive control group and was put to comparison with methanolic extract of UPL (20 mg/kg; IP), three doses of decocted extract of UPL (20, 40 and 80 mg/kg; IP) and a group of distilled water (6 ml/kg; IP). The differences were estimated by means of one-way ANOVA followed by LSD test for acute anti-inflammatory studies (One hour after formalin injection), and by means of Student's unpaired t-test for the chronic studies (Day one to day seven edema surveys).
In Acute anti-inflammatory studies, two doses of decocted UPL extract (40 mg/kg and 80 mg/kg) and S.S group had anti-inflammatory effects (p-value<0.05). In chronic anti- inflammatory studies results indicate that all UPL extract groups (20 mg/kg, 40 mg/kg and 80 mg/kg decocted extract groups and 20 mg/kg methanolic extract group) had anti- inflammatory effects (P-value<0.05) which had no significant difference with the S.S group.
Urtica pilulifera l. seeds had acute and chronic anti-inflammatory effects which its decocted extracts had significant effects in acute anti-inflammatory studies and both methanolic and decocted extracts had significant effects in chronic studies.