Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
The effects of hydro-alcoholic extract of Coriandrum sativum on anxiety reaction in Mice
Vafaei A.A., Taherian A.A.
Department of Physiology and Pharmacology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
In recently, many studies tried that fine medicinal plant that may be useful in treatment of psychological diseases. Coriandrum sativum (CS) overgrows in the different parts of Iran. In this study we investigated the effects of hydro-alcoholic extract of Coriandrum sativum on anxiety reaction in Mice.
In this study, fourty male mice (25-30 gr) in elevated plus maze model were used. Different doses of the extract of CS (100, 250 and 500 mg/kg IP) were injected to the separated groups of three (test group) and vehicle were injected to control group the same volum. At the first time for increasing activity animals have put inside the black wall box for 5 min. Then animal transfer to the elevated plus maze and evaluation their anxiety reaction that including of number intrances to open arm and percent of time spent in open arm.
Results indicated that injection of extract of CS in dose dependently reduced of reaction anxiety and with compare to control group in the test group animals have more number of entrances and spent more percent time in open arm (P<0.01).
Finding above showed that the dycro-alcoholic extract of CS plays an important role in fear and anxiety and hypnotic which is related to dose.