Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Investigation the effects of extract of Foeniculum vulgare on anxiety in mice
Vafaei A.A., Taherian A.A.
Department of Physiology and Pharmacology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Previous studies indicated that Foeniculum vulgare (FV) as a folk remedy plant that overgrows in the different parts of Iran and suggested that have antinociceptive activity and sedative. In this study, we investigated of anxiolytic effects in different doses of the extracts of FV.
In this study, fourty male mice (25-30 gr) were used in elevated plus maze model. Different doses of the extract of FV (100, 200 and 400 mg/kg IP) were injected to the separated groups of Three (test group) and saline were injected to the control group the same volume. At the first time for increasing activity, animals have put inside the black wall box for 5 min. Then animal transfer to the elevated plus maze and evaluation their anxiety reaction that including of number and percent of time spent in open arm.
Results indicated that injection of extract of FV reduced reaction anxiety in dose dependently manner and with compare to saline group in the test group animals had more number of entrances and spent more percent time in open arm (P<0.01).
Finding above showed that the extract of FV plays an important role in fear and anxiety and hypnotic which is related to dose.