Rasekh, H., Hoseinzadeh, I., Nazari, P., Kamalinejad, M. (2010). Acute toxicity of galega officinalis alcoholic extract in wistar rats. Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), 45-45. doi: 10.22037/ijpr.2010.427
H Rasekh; I Hoseinzadeh; P Nazari; M Kamalinejad. "Acute toxicity of galega officinalis alcoholic extract in wistar rats". Iranian Journal of Pharmaceutical Research, Volume 3, Supplement 2, 2010, 45-45. doi: 10.22037/ijpr.2010.427
Rasekh, H., Hoseinzadeh, I., Nazari, P., Kamalinejad, M. (2010). 'Acute toxicity of galega officinalis alcoholic extract in wistar rats', Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), pp. 45-45. doi: 10.22037/ijpr.2010.427
Rasekh, H., Hoseinzadeh, I., Nazari, P., Kamalinejad, M. Acute toxicity of galega officinalis alcoholic extract in wistar rats. Iranian Journal of Pharmaceutical Research, 2010; Volume 3(Supplement 2): 45-45. doi: 10.22037/ijpr.2010.427
Acute toxicity of galega officinalis alcoholic extract in wistar rats
Galega officinalis (galega, Goat`s rue, French lilac) is a traditional plant from south east Europe. There are various reports about pharmacological properties of Galega officinalis such as diuretic, platelet aggregation, anti-bacterial, lactogen and anti-diabetic effect. There are a few studies about possible toxicological effect of this plant. In the present study, we evaluated the acute toxicity of Galega officinalis in rats.
Wistar rats (20 male, 20 female) were divided at random into five-dose groups and were gavaged with 0, 0.5, 1, 2.5, 5 mg/kg of alcoholic extract (Single dose). The rats were observed for 14 days after treatment for clinical singes of toxicity and dead animal count also animals were weight weekly.
After 14 days all them survived and there was no significant difference in body weight in both sexes as compared to their respective control.
Present data suggest that LD50 of Galega officinalis is higher than 5 mg/kg. However, more studies are required for evaluation of Galega officinalis safety such as assessment of subchronic and chronic toxicity.
Full Text
Iranian Journal of Pharmaceutical Research (2004): Supplement 2
Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
45-45
Poster Presentations/Ethnopharmacology
2nd International Congress on Traditional Medicine and Materia Medica October 4-7, 2004, Tehran, Iran
129
Acute toxicity of
Galega officinalis alcoholic extract in wistar rats
Rasekh H., Hoseinzadeh I.,
Nazari P., Kamalinejad M.
Departmant of
Toxicology and Pharmacology, Pharmacy School, Shaheed Beheshti Univresity of
Medical Sciences
Galega officinalis
(galega, Goat`s rue, French lilac) is a traditional plant from south east
Europe. There are various reports about pharmacological properties of Galega
officinalis such as diuretic, platelet aggregation, anti-bacterial, lactogen
and anti-diabetic effect. There are a few studies about possible toxicological
effect of this plant. In the present study, we evaluated the acute toxicity of
Galega officinalis in rats.
Wistar rats (20 male, 20 female) were divided at random into five-dose groups
and were gavaged with 0, 0.5, 1, 2.5, 5 mg/kg of alcoholic extract (Single
dose). The rats were observed for 14 days after treatment for clinical singes of
toxicity and dead animal count also animals were weight weekly.
After 14 days all them survived and there was no significant difference in body
weight in both sexes as compared to their respective control.
Present data suggest that LD50 of Galega officinalis is higher than 5
mg/kg. However, more studies are required for evaluation of Galega
officinalis safety such as assessment of subchronic and chronic toxicity.
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