Effect of Glycyrrhiza glabra extract on wound tensile strength in albino rats

Authors

Abstract

Glycyrrhiza glabra extract is gaining increasing acceptance as a folk remedy for treatment of wound. We studied the effect of its extract on wound tensile strength in albino rats.
20 male albino rats had a linear 3 cm incision made over skin of back. The animals were randomly divided into two experimental groups, as control and treatment. Animals of control group received topical cold cream once a day from day 0 (beginning of experiments) to day 30 (Two weeks after complete wound closure). Animals of treatment group treated topically by Glycyrrhiza glabra extract cream at the same time. Wound tensile strength was measured in all of animals at the end of experiments by a tensiometric method.
There was no statistically significant difference between the mean of tensile strength in treatment and control animals.
We conclude that topically administration of Glycyrrhiza glabra extract hasn’t beneficial effects on tensile strength of wound healing in an incisional wound model in rats.

Iranian Journal of Pharmaceutical Research (2004): Supplement 2

Iranian Journal of Pharmaceutical Research (2004): Supplement 2: 44-44
Poster Presentations/Ethnopharmacology

2nd International Congress on Traditional Medicine and Materia Medica
October 4-7, 2004, Tehran, Iran

126

Effect of Glycyrrhiza glabra extract on wound tensile strength in albino rats

Jarrahi M., Vafaei A.A., Miladi-Gorgi H., Taherian A, A.

Department of Physiology and Pharmacology, Faculty of Medicine, University of Medical Sciences, Semnan, Iran

Glycyrrhiza glabra extract is gaining increasing acceptance as a folk remedy for treatment of wound. We studied the effect of its extract on wound tensile strength in albino rats.

20 male albino rats had a linear 3 cm incision made over skin of back. The animals were randomly divided into two experimental groups, as control and treatment. Animals of control group received topical cold cream once a day from day 0 (beginning of experiments) to day 30 (Two weeks after complete wound closure). Animals of treatment group treated topically by Glycyrrhiza glabra extract cream at the same time. Wound tensile strength was measured in all of animals at the end of experiments by a tensiometric method.

There was no statistically significant difference between the mean of tensile strength in treatment and control animals.

We conclude that topically administration of Glycyrrhiza glabra extract hasn’t beneficial effects on tensile strength of wound healing in an incisional wound model in rats.

Presenting Author: Jarrahi, M. aavaf43@yahoo.com