Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Effect of crushed garlic extract on wound healing in albino rats
Jarrahi M., Vafaei A.A.
Department of Physiology and Pharmacology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Garlic extract is gaining increasing acceptance as an antimicrobial and anti-inflammatory agent and as a folk remedy on wound healing. We studied the effect of crushed garlic extract on wound healing in albino rats.
20 male albino rats had a linear 3 cm incision made over skin of back. The animals were randomly divided into two experimental groups, as control and treatment. Animals of control group received topical cold cream once a day from beginning of experiments to complete wound closure. Animals of treatment group treated topically by crushed garlic extract cream at the same time. For computing the percent of wound healing, the area of wound was measured at the beginning of experiments and 2, 4, 6, 8, 10, 12, 14 and 16 days after that.
There was statistically significant difference between treatment and control animals in some of days (P<0.05).
We conclude that topically administration of crushed garlic extract has beneficial effects on the rate of wound closing an incisional wound model in rats.