Jabeen, Q., Ghufran, A., Khan, S., Hotchand, A., Gilani, A., Ahmad, V., Ahmed, A., Rasheed, M. (2010). Ethnopharmacological evaluation of antisplasmodic activity of essential oils from different plants. Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), 44-44.
Q Jabeen; A Ghufran; SF Khan; A Hotchand; AH Gilani; VU Ahmad; A Ahmed; M Rasheed. "Ethnopharmacological evaluation of antisplasmodic activity of essential oils from different plants". Iranian Journal of Pharmaceutical Research, Volume 3, Supplement 2, 2010, 44-44.
Jabeen, Q., Ghufran, A., Khan, S., Hotchand, A., Gilani, A., Ahmad, V., Ahmed, A., Rasheed, M. (2010). 'Ethnopharmacological evaluation of antisplasmodic activity of essential oils from different plants', Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2), pp. 44-44.
Jabeen, Q., Ghufran, A., Khan, S., Hotchand, A., Gilani, A., Ahmad, V., Ahmed, A., Rasheed, M. Ethnopharmacological evaluation of antisplasmodic activity of essential oils from different plants. Iranian Journal of Pharmaceutical Research, 2010; Volume 3(Supplement 2): 44-44.
Ethnopharmacological evaluation of antisplasmodic activity of essential oils from different plants
Achillea santolina, Nepeta cataria and Salvia bucharica are mainly known to possess antispasmodic use in traditional medicine. The essential oils from these plants were screened for their possible pharmacological activity with possible mode of action explored.
Volatile oil was extracted by steam distillation using standard procedure given in British Pharmacopoeia 2001. For pharmacological activity, rabbits were killed by cervical dislocation and jejunum was dissected out. About 2 cm pieces of rabbit jejunum were suspended separately in 10 ml isolated tissue baths containing Tyrode’s solution maintained at 37?C and aerated with carbogen. The responses were recorded on the Harvard Student Oscillograph.
The oils, after solubilizing in different solvent systems according to their solubility, showed dose-dependent relaxation of spontaneous contractions of rabbit jejunum thus showing spasmolytic activity. The effect was dose-dependent, mediated at the dose range of 0.01-0.3 mg/ml. When tested on high K+ (80 mM)-induced contractions, the oils from all plants showed varying degree of relaxant effect observed at the dose range of 0.01-0.3 mg/ml.
This study indicates that the spasmolytic effect is mediated through the presence of calcium channel blocking constituents in these plants, and thus provides sound scientific base for some of the traditional uses of the plants.
Full Text
Iranian Journal of Pharmaceutical Research (2004): Supplement 2
Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
44-44
Poster Presentations/Ethnopharmacology
2nd International Congress on Traditional Medicine and Materia Medica October 4-7, 2004, Tehran, Iran
124
Ethnopharmacological
evaluation of antisplasmodic activity of essential oils from different plants
Jabeen Q.1, Ghufran
A.1, Khan S.F.1, Hotchand A.1, Gilani A.H.1,
Ahmad V.U.2, Ahmed A.2, Rasheed M.2
1Department
of Biological and Biomedical Sciences, The Aga Khan University, Karachi 2HEJ
Research Institute of Chemistry, Karachi, Pakistan
Achillea santolina, Nepeta cataria
and Salvia bucharica are mainly known to possess antispasmodic use in
traditional medicine. The essential oils from these plants were screened for
their possible pharmacological activity with possible mode of action explored.
Volatile oil was extracted by steam distillation using standard procedure given
in British Pharmacopoeia 2001. For pharmacological activity, rabbits were killed
by cervical dislocation and jejunum was dissected out. About 2 cm pieces of
rabbit jejunum were suspended separately in 10 ml isolated tissue baths
containing Tyrode’s solution maintained at 37ºC and aerated with carbogen. The
responses were recorded on the Harvard Student Oscillograph.
The oils, after solubilizing in different solvent systems according to their
solubility, showed dose-dependent relaxation of spontaneous contractions of
rabbit jejunum thus showing spasmolytic activity. The effect was dose-dependent,
mediated at the dose range of 0.01-0.3 mg/ml. When tested on high K+ (80
mM)-induced contractions, the oils from all plants showed varying degree of
relaxant effect observed at the dose range of 0.01-0.3 mg/ml.
This study indicates that the spasmolytic effect is mediated through the
presence of calcium channel blocking constituents in these plants, and thus
provides sound scientific base for some of the traditional uses of the plants.
Top