Iranian Journal of Pharmaceutical Research (2004): Supplement 2:
2nd International Congress on Traditional Medicine and Materia Medica
Zataria multiflora vaginal cream compared with Clotrimazole vaginal cream in the treatment of Candida vaginitis
Islami A1, Ansari A1, Kashanian M2., Bekhradi R2., Akbari M2, Akbari H3, Darabi2
1Kashan University of Medical Scineces 2Research and Development Department of Barij Essence Pharmaceutical Co. 3Kashan Faculty of Hygiene
To determine the effect of Zataria multiflora vaginal cream in signs & symptoms of Candida vaginits.
A randomized, double-blind clinical trial was performed comparing one applicator of Zataria multiflora vaginal cream with one applicator of Clotrimazole vaginal cream at night for a week.
61 women with candida vaginitis were enrolled. 30 of 62 women treated with Zataria multiflora vaginal cream and 31 of 62 women with Clotrimazole vaginal cream.
Zataria multiflora vaginal cream Significantly reduced all symptoms except vaginal irritation & burning (P<0.05).
The effects of Zataria multiflora vaginal cream on gynecologic signs was superior to Clotrimazole vaginal cream.
According to results of vaginal discharge microscopic Study; there was no significant difference between two cream. (P>0.05).
No difference in efficacy of two cream was noted, according to overall assessment by the clinicians. (P=0.071).
There was no significant adverse reactions in 2 groups.
A 7-day regimen of Zataria multiflora given as intravaginal cream was more effective than a 7-day regimen of Clotrimazole vaginal cream for treatment of Candida vaginits.