Document Type : Research article
Foundation of Technical Education, College of Health and Medical Technology, Baghdad, Iraq.
Department of Dental Biomaterials, School of Dentistry, International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, Iran.
Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
The purpose of this study was to investigate the antimicrobial properties of a conventional
poly methyl methacrylate (PMMA) modified with hydrothermally synthesised titanium
dioxide nanotubes (TNTs). Minimum inhibitory concentration (MIC), minimum bactericidal
concentration (MBC), and minimum fungicidal concentrations (MFC) for planktonic cells
of the TiO2 nanotubes solution against Lactobacillus acidophilus, Streptococcus mutans and
Candida albicans were determined. The powder of conventional acrylic resin was modified
using 2.5% and 5% by weight synthesised titanium dioxide (TiO2) nanotubes, and rectangularshaped
specimens (10 mm × 10 mm × 3 mm) were fabricated. The antimicrobial properties
of ultraviolet (UV) and non-UV irradiated modified, and non-modified acrylic resins were
evaluated using the estimation of planktonic cell count and biofilm formation of the three
microorganisms mentioned above. The data were analysed by one-way analysis of variance
(ANOVA), followed by a post-hoc Tukey’s test at a significance level of 5%. MIC, for
Streptococcus. mutans, Lactobacillus. acidophilus, and Candida. albicans, MBC for S. mutans
and L. acidophilus and MFC for Candida. albicans were obtained more than 2100 μg/mL.
The results of this study indicated a significant reduction in both planktonic cell count and
biofilm formation of modified UV-activated acrylic specimens compared with the control
group (p = 0.00). According to the results of the current study, it can be concluded that PMMA/
TiO2 nanotube composite can be considered as a promising new material for antimicrobial