Reduction of some atherogenic indices in patients with non-alcoholic fatty liver by Vitamin D and calcium co-supplementation: a double blind randomized controlled clinical trial

Document Type: Research article

Authors

1 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

2 Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.

3 Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

4 Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

5 Department of Applied chemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Isalmic Azad University, Tehran, Iran.

6 Department of Cardiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Abstract

The role of non-alcoholic fatty liver disease (NAFLD) as a potential independent cardiovascular disease (CVD) risk factor has recently gained considerable attention because CVD is the common cause of death in NAFLD patients. We aimed to estimate the effects of vitamin D supplementation alone or in combination with calcium on atherogenic indices, liver function tests and grade of disease in patients with NAFLD. One-hundred twenty NAFLD patients were randomized in a double-blind, placebo-controlled clinical trial as follows: D (1000 IU vitamin D), CaD (500 mg as calcium carbonate plus 1000 IU vitamin D) or P (placebo), once daily with meals over 12 weeks. Adjusted for all the baseline measures, reduction in serum ALT, AST, LDL-C/HDL-C, TC/HDL-C and non-HDL-C were significantly higher in the CaD compared with the P group (p

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