Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities

Document Type: Research article

Authors

1 Department of Chemistry, College of Sciences, Shiraz University, Shiraz, Iran

2 UMR-MD3 Relation hoˆte-parasites, Physiopathologie and Pharmacologie, Faculte´ de Pharmacie, Aix-Marseille Universite´, Bd Jean Moulin, Marseille, 13385, France.

3 Centre de Recherche en Cance´rologie de Marseille (CRCM), UM 105, CNRS, UMR7258, Institut Paoli Calmettes, Inserm, U1068, Faculte´ de Pharmacie, Aix-Marseille Universite´, Bd Jean Moulin, Marseille, 13385, France.

4 Department of Chemistry, Dhote Bandhu Science College, Gondia, 441614 India.

5 Laboratoire de Chimie des Matériaux (LCM), Département de Chimie, Facultés des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco.

Abstract

Some new b-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino b-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC50 values.
 
 

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