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Iranian Journal of Pharmaceutical Research
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Hesami, O., Shams, M., Ayazkhoo, L., Assarzadegan, F., Safarpour Lima, B., Delavar Kasmaei, H., Sistanizad, M. (2018). Comparison of Pregabalin and Sodium Valproate in Migraine Prophylaxis: A Randomized Double-Blinded Study. Iranian Journal of Pharmaceutical Research, 17(2), 783-789.
Omid Hesami; Mohammad Reza Shams; Ladan Ayazkhoo; Farhad Assarzadegan; Behnam Safarpour Lima; Hosein Delavar Kasmaei; Mohammad Sistanizad. "Comparison of Pregabalin and Sodium Valproate in Migraine Prophylaxis: A Randomized Double-Blinded Study". Iranian Journal of Pharmaceutical Research, 17, 2, 2018, 783-789.
Hesami, O., Shams, M., Ayazkhoo, L., Assarzadegan, F., Safarpour Lima, B., Delavar Kasmaei, H., Sistanizad, M. (2018). 'Comparison of Pregabalin and Sodium Valproate in Migraine Prophylaxis: A Randomized Double-Blinded Study', Iranian Journal of Pharmaceutical Research, 17(2), pp. 783-789.
Hesami, O., Shams, M., Ayazkhoo, L., Assarzadegan, F., Safarpour Lima, B., Delavar Kasmaei, H., Sistanizad, M. Comparison of Pregabalin and Sodium Valproate in Migraine Prophylaxis: A Randomized Double-Blinded Study. Iranian Journal of Pharmaceutical Research, 2018; 17(2): 783-789.

Comparison of Pregabalin and Sodium Valproate in Migraine Prophylaxis: A Randomized Double-Blinded Study

Article 33, Volume 17, Issue 2, Spring 2018, Page 783-789  XML PDF (445 K)
Document Type: Research article
Authors
Omid Hesami1; Mohammad Reza Shams2; Ladan Ayazkhoo3; Farhad Assarzadegan1; Behnam Safarpour Lima1; Hosein Delavar Kasmaei4; Mohammad Sistanizad 5, 6
1Department of Neurology, Emam Hossein Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Department of Neurology, Besat Hospital, Military University of Medical Sciences, Tehran, Iran.
3Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4Department of Neurology, Shohada Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6Department of Pharmaceutical Care Unit, Emam Hossein Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
Patients suffering from headache, particularly migraine type, are among the most dissatisfied patients. The aim of this study was comparing the efficacy of pregabalin with valproate sodium, in preventing migraine headache.
In a randomized, double-blinded study, adult patients eligible for prophylactic treatment (i.e., patients with 4-15 attacks per month in last two months) were recruited. Patients’ demographic data, duration of symptoms, headache frequency (attacks per month) and intensity (based on visual analogue scale) and also drugs used to relief headache were recorded. The patients were randomly assigned to two groups; valproate sodium (200 mg two times daily) and pregabalin (50 mg two times daily). The patients were examined by neurology specialist monthly for three months and the related data were recorded. The Data were analyzed using SPSS version 21, with related statistical tests.
Total number of 140 patients with recurrent migraine were entered into the study. Sixty-nine patients were assigned to group A and 71 to group B by the randomizing table. Inter-group analysis of data in two arms of the study showed that two medications were equally effective except that pregabalin was not significantly effective in reducing number of attacks during first month of therapy compared to baseline. This differences were not significant at second and third month of the study.
Our study showed that pregabalin, has comparable efficacy with valproate sodium in reducing migraine frequency, intensity, and duration of attacks and could be an alternative for migraine prophylaxis.
Keywords
Migraine; Prophylaxis; pregabalin; Valproate sodium; Headache
Main Subjects
Pharmacotherapy (Clinical Pharmacy)
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