Design, Synthesis and Antitubercular Evaluation of Novel Series of Pyrazinecarboxamide Metal Complexes

Document Type: Research article

Authors

1 Department of Chemistry, University of Karachi, Karachi-75270, Pakistan.

2 Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan

3 Department of Microbiology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

4 Department of Biotechnology, University of Karachi, Karachi-75270, Pakistan

5 Department of Chemistry, University of Karachi, Karachi-75270, Pakistan

6 Phytochemistry Research Center and Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

The interest in the synthesis of metallic complexes of different drugs to make them more
efficient in biological environment of the human body is seen for the last few decades. Wide
range of metal complexes are already used in clinical practice which encourages additional
research for innovating new metal based drugs, such as metal-mediated antibiotics, antiparasitic,
antiviral, antibacterial, and anticancer compounds. Tuberculosis has been known as
one of the most disastrous disease putting burden on health system worldwide. Though the
therapeutic agents to combat the disease are well practiced, emergence of multi drug resistant
strains makes the treatment strategies more difficult. The following work aims to synthesize
copper, ferrous, ferric, cobalt and manganese complexes of renowned anti tuberculosis drug,
pyrazinamide (PZ). These compounds were tested for anti-tuberculosis using five multidrug
resistant strain of Mycobacterium tuberculosis. For this purpose BACTEC MGIT 960 system
was used. The drug PZ was also screened with the synthesized complexes. The two complexes
of cobalt and manganese proved potent among all of the compounds tested.

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