Ameliorative Effect of Beraprost Sodium on Celecoxib Induced Cardiotoxicity in Rats

Document Type: Research article

Authors

1 Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

2 Department of Anatomy and Physiology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.

3 Department of Life Sciences, Indira Gandhi National Open University, New Delhi, India.

Abstract

Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;
however, its maximal use is highly associated with various serious abnormal cardiovascular
events. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,
antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study was
to evaluate the effect of BPS on celecoxib cardiotoxicity in rats. Toxicity was induced in male
Albino rats (250-280 g) by celecoxib (100 mg/kg/day). BPS (30 μg/kg/day) was administered
alone and in combination with celecoxib for 14 days and various biochemicals, hemodynamic,
left ventricular, biochemical, and histopathological parameters were studied. Cardiotoxicity
of celecoxib was revealed by a significant increase in serum lactate dehydrogenase
(LDH), troponin-T (Tn-T), tumor necrosis factor-α (TNF- α), creatine kinase-MB (CK-MB)
and systolic blood pressure (SBP), left ventricular end diastolic pressure (LVEDP), LV (dp/
dt)max, and LV (dp/dt)min as well as tissue thiobarbituric acid reactive substance (TBARS)
and a significant decrease in tissue reduced glutathione (GSH). However, treatment with
BPS reversed these alteration in LDH, Tn-T, TNF-α, CK-MB, SBP, LVEDP, LV (dp/dt)max,
LV (dp/dt)min, TBARS and GSH levels. The histopathological study in cardiac left ventricle
revealed protection of myocardium as manifested reduction of fibrosis by abolition of collagen
deposition when celecoxib was combined with beraprost sodium. It could be concluded that
beraprost sodium may prove a useful adjunct in patients being prescribed celecoxib.

Keywords

Main Subjects