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Iranian Journal of Pharmaceutical Research
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Venkatesh, T., Bodke, Y., Joy, N., D, B., Ramakrishnan, S. (2018). Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents. Iranian Journal of Pharmaceutical Research, 17(1), 75-86. doi: 10.22037/ijpr.2018.2181
Talavara Venkatesh; Yadav Bodke; Nibin Joy; Bhadrapura D; Siva Ramakrishnan. "Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents". Iranian Journal of Pharmaceutical Research, 17, 1, 2018, 75-86. doi: 10.22037/ijpr.2018.2181
Venkatesh, T., Bodke, Y., Joy, N., D, B., Ramakrishnan, S. (2018). 'Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents', Iranian Journal of Pharmaceutical Research, 17(1), pp. 75-86. doi: 10.22037/ijpr.2018.2181
Venkatesh, T., Bodke, Y., Joy, N., D, B., Ramakrishnan, S. Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents. Iranian Journal of Pharmaceutical Research, 2018; 17(1): 75-86. doi: 10.22037/ijpr.2018.2181

Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents

Article 7, Volume 17, Issue 1, Winter 2018, Page 75-86  XML PDF (732.43 K)
Document Type: Research article
DOI: 10.22037/ijpr.2018.2181
Authors
Talavara Venkatesh1; Yadav Bodke email 1; Nibin Joy1; Bhadrapura D2; Siva Ramakrishnan3
1Department of P.G. Studies and Research in Industrial Chemistry, Jnana Sahyadri, Kuvempu University Shankaraghatta, Shivamogga, Karnataka, India.
2Toxinology/Toxicology and Drug Discovery Unit, Centre for Emerging Technologies (CET), Jain University, Kanakpura Taluk, Ramanagara India.
3Cardiomyocyte Toxicity and Oncology Research Laboratory, Department of Bioinformatics, SCBT, Sastra University, Thanjavur, India.
Abstract
In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuran
chalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. The structures
of title compounds (4a-d), (5a-d) and (6a-d) were established on the basis of analytical
and spectral data. The synthesized compounds were screened for antimicrobial activity
and molecular docking studies. Some of the compounds displayed excellent antimicrobial
activity. The molecular docking analysis revealed that compounds 5a and 5c with the lowest
binding energy in comparison to others suggesting its potential as best inhibitor of GluN-6-P.
Consequently, it is confirmed from the above analysis that the compounds 5a and 5c might
serve as a useful backbone scaffold for rational design, adaptation and investigation of more
active analogs as potential broad spectrum antimicrobial agents.

Keywords
Benzofuran chalcones; Hydroxy pyrimidines; Thiopyrimidines; Amino pyrimidines; Antimicrobial activity; Molecular docking studies
Main Subjects
Medicinal chemistry
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