Antidepressant-like Effect of a Chalcone Compound, DHIPC and Its Possible Mechanism

Document Type: Research article

Authors

1 Department of Pathology, Jilin Medical University, Jilin, Jilin Province 132013, P. R. China.

2 Department of Obstetrics and Gynecology, Second hospital, Jilin University, Changchun 130041, P. R. China.

3 Food and Pharmacy College, Zhejiang Ocean University, Zhoushan, Zhejiang, 316022, P. R. China.

Abstract

DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalcone
compound. In this study, its antidepressant-like activity of compound DHIPC was evaluated by
the forced swimming test and the tail suspension test in mice. The results showed that DHIPC
significantly reduced the immobility time for 2 h after treatment through the oral administration
at dose of 10, 20, and 30 mg/kg in the forced swimming test and the tail suspension test,
indicating a significant antidepressant-like effect. The maximal effect was obtained at 30 mg/
kg, which is similar to the positive control fluoxetine. The main monoamine neurotransmitters
and their metabolites in rat brain were also simultaneously determined. It was found that
DHIPC significantly increased the concentrations of the main neurotransmitters serotonin
and noradrenalin, and also significantly increased 5-hydroxyindoleacetic acid contents in
hippocampus, hypothalamus, and cortex in brain part. So, the probable mechanism of action of
DHIPC is thought to be related to increase in serotonin and noradrenalin in the brain.

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