Synergistic Effect of ZnO Nanoparticles and Carbon Nanotube and Polymeric Film on Electrochemical Oxidation of Acyclovir

Document Type: Research article


Department of Chemistry, Payame Noor University, Tehran, Iran.


A simple and selective carbon paste electrode has been developed for the electrochemical
determination of acyclovir (ACV). This electrode was designed by incorporation of multiwalled
carbon nanotubes (MWCNTs) and ZnO nanoparticles into the carbon paste matrix,
and then poly (o-aminophenol; OAP) film were subsequently electropolymerized on it. The
surface structure of nanoparticles were characterized by scanning electron microscopy (SEM)
and transmission electron microscopy (TEM). Surface morphology and electrochemical
properties of the prepared nanocomposite modified electrode were investigated by SEM and
cyclic voltammetry (CV). The calibration graph was linear over the concentration range 0.089
to 7.96 μg mL-1 for ACV determination with a detection limit of 0.067 μg mL-1. The proposed
electrode was successfully applied for ACV determination in pharmaceutical formulations with
satisfactory results.


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