Anti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats

Document Type: Research article

Authors

1 Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

3 The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

4 Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

5 Histomorphometry and Stereology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugar
and abnormalities in insulin secretion and action. There are many anti-diabetic plants, which
might supply useful sources for developing new medicines that can be used in treatment of
diabetes mellitus. The primary objective of the present investigation is to evaluate the antidiabetic
properties of the aerial parts of Amygdalus lycioides in streptozocin-induced diabetic
rats. Sixty rats were divided into 6 groups: streptozocin-induced diabetic control, insulintreated
diabetic group, and four Amygdalus lycioides-treated diabetic groups (125, 250, 500,
and 1000 mg/kg/day). After 2 weeks of plant extract administration, the effects of extracts on
blood glucose, body weight, BUN, creatinine, total cholesterol, LDL, HDL, triglyceride, total
protein, Na, K, and plasma enzymes (aspartate aminotransferase, alanine aminotransferase and
alkaline phosphatase) were analyzed. The pancreas of rats was also stained for stereological
studies. Phytochemical evaluation of this extract showed the presence of flavonoids and tannins
compounds. Glucose serum levels and glucose tolerance test showed a decrease in treatment
with Amygdalus lycioides (1000 mg/kg). Serum total cholesterol, LDL, triglyceride, creatinine
and alkaline phosphatase levels were decreased significantly by the extract but aspartate
aminotransferase found to be increased after treatment. The total number and numerical density
of beta cells increased in the Amygdalus lycioides group (1000 mg/kg). It seems that Amygdalus
lycioides may act as a potential drug to treat diabetes and its complications. However, more
investigations should be done to more clarify these results.

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