Shamasabadipour, S., Zarei, S., Ghanadian, M., Ayatollahi, S., Rahimnejad, M., Saeedi, H., Aghaei, M. (2018). A New Taraxastane Triterpene from Euphorbia Denticulata with Cytotoxic Activity Against Prostate Cancer Cells. Iranian Journal of Pharmaceutical Research, 17(1), 336-342. doi: 10.22037/ijpr.2018.2156
Sara Shamasabadipour; Seyed Mohammad Zarei; Mustafa Ghanadian; seyed abdulmajid Ayatollahi; Mohammad Reza Rahimnejad; Hojjatollah Saeedi; Mahmoud Aghaei. "A New Taraxastane Triterpene from Euphorbia Denticulata with Cytotoxic Activity Against Prostate Cancer Cells". Iranian Journal of Pharmaceutical Research, 17, 1, 2018, 336-342. doi: 10.22037/ijpr.2018.2156
Shamasabadipour, S., Zarei, S., Ghanadian, M., Ayatollahi, S., Rahimnejad, M., Saeedi, H., Aghaei, M. (2018). 'A New Taraxastane Triterpene from Euphorbia Denticulata with Cytotoxic Activity Against Prostate Cancer Cells', Iranian Journal of Pharmaceutical Research, 17(1), pp. 336-342. doi: 10.22037/ijpr.2018.2156
Shamasabadipour, S., Zarei, S., Ghanadian, M., Ayatollahi, S., Rahimnejad, M., Saeedi, H., Aghaei, M. A New Taraxastane Triterpene from Euphorbia Denticulata with Cytotoxic Activity Against Prostate Cancer Cells. Iranian Journal of Pharmaceutical Research, 2018; 17(1): 336-342. doi: 10.22037/ijpr.2018.2156
A New Taraxastane Triterpene from Euphorbia Denticulata with Cytotoxic Activity Against Prostate Cancer Cells
1Department of Biology, Faculty of Science, University of Isfahan, Isfahan, I.R. Iran.
2School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
3Pharmacognosy department, Isfahan Faculty of Pharmacy, Isfahan University of Medical Sciences
4Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran
Abstract
In this research, aerial parts of Euphorbia denticulata Lam were collected from Sanandaj city in Kurdistan province at the West of Iran. It was extracted by maceration using acetone as solvent. Isolation of compounds were carried out with repeated column chromatography using silica gel and normal preparative HPLC using YMC-Pack-Sil column and hexane: ethyl acetate as mobile phase. The structures of isolated compounds were elucidated by extensive 1 and 2D-NMR as well as HRESI-MS spectra and the cytotoxicity was done against DU-145 human prostate cancer cell line using standard MTT assay. It afforded a new 12-taraxastane derivative and two known cycloartane triterpenes including: taraxast-12-ene-3β,20,21(α)-triol (1), cycloartane-3β,25-diol (2) and cycloartane-3β,24,25-triol (3). They exhibited cytotoxic effects, with IC50 values of 12.2±2.9, 27.5±4.9 and 18.3±1.4 µM, respectively.
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