Motaharinia, J., Mojtahedzadeh, M., Etezadi, F., Pourmand, G., Najafi Abrandabadi, A. (2017). Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation (autumn 2017). Iranian Journal of Pharmaceutical Research, (), -.
Javad Motaharinia; Mojtaba Mojtahedzadeh; Farhad Etezadi; Gholamreza Pourmand; Amir Hossein Najafi Abrandabadi. "Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation (autumn 2017)". Iranian Journal of Pharmaceutical Research, , , 2017, -.
Motaharinia, J., Mojtahedzadeh, M., Etezadi, F., Pourmand, G., Najafi Abrandabadi, A. (2017). 'Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation (autumn 2017)', Iranian Journal of Pharmaceutical Research, (), pp. -.
Motaharinia, J., Mojtahedzadeh, M., Etezadi, F., Pourmand, G., Najafi Abrandabadi, A. Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation (autumn 2017). Iranian Journal of Pharmaceutical Research, 2017; (): -.
Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation (autumn 2017)
1Department of Clinical Pharmacy, Tehran University of Medical Sciences
2Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences
3Department of Anesthesiology & Critical Care, Sina Hospital, Tehran University of Medical Sciences
4Urology Research Center, Tehran University of Medical Sciences
Abstract
Background: Ischemia reperfusion injury (IRI) is one of the main causes of delay graft function (DGF) in deceased-donor kidney transplantation (DDKT). Evidences suggest that hypertonic saline (HS) has beneficial effects on IRI. Objectives: To determine the effect of intraoperative HS, on early graft function and urinary biomarkers of interleukin 18 (IL-18) and neutrophil gelatinase-associated lipocalin (NGAL), in patients with DDKT. Design: Randomized, open-label, case-control, trial in patients with DDKT. Intervention: Administration of 4 ml/kg HS, 5% before graft reperfusion. The primary endpoint was graft function categorized as immediate, slow, and delayed graft function. The secondary endpoints were acute rejection, and urinary IL-18 and NGAL at 2, 24 and 48 h post-transplant. Results: Fifty-eight (58) adult patients were randomized (HS, n=32; control, n=26). There were no significant differences between the two groups in terms of recipient, donor, and transplant characteristics. The rate of DGF was 12% in the HS group compared with 28.5% in the control group (p=0.056). The urinary NGAL and IL-18 were lower in HS vs the control, at all time points. Moderate metabolic acidosis occurred only in one patient, after HS administration. No electrolyte or hemodynamic abnormality was observed in the patients receiving HS. Conclusions: The bolus administration of a single dose of HS before graft reperfusion is safe and seems to be effective in improving short-term graft function, in patients with DDKT. This study shows that measurement of 24 h post-transplant urinary NGAL and IL-18, may be useful in the predication of DGF in patients with DDKT.
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