Anticonvulsant Effects of New 1, 4-Dihydropyridine Derivatives Containing Imidazolyl Moiety Against Seizures Induced by Pentylenetetrazole and Maximal Electroshock in Mice

Document Type: Research article

Authors

1 Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran (IAUPS).

3 Department of Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

4 Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world.
Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In this
paper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3,
5-dicarboxamides was performed.
Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetrazole
and maximal electroshock induced seizures tests. Nifedipine was used as reference drug. Our
pharmacological results revealing the compounds 2, 4, 5, and 6 can be effective in both absence
and grandmal seizures in human.
These pharmacological studies have displayed that these new dihydropyridine derivatives
are capable to inhibiting seizures induced by pentylenetetrazole and maximal electroshock in
mice efficiently.

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