Investigating The Role of Novel Bioactive Compound from Ficus Virens Ait on Cigarette Smoke Induced Oxidative Stress and Hyperlipidemia in Rats

Document Type: Research article

Authors

1 Clinical Biochemistry and Natural Product Research Laboratory, Department of Biosciences, Integral University Lucknow-226026, India.

2 Department of Medical Laboratory Sciences, College of Applied medical Sciences, Majmaah University, Al-majma’ah-11952, Saudi Arabia

3 Department of Maxillofacial Surgery (Biochemistry), College of Dentistry, Taif University, KSA.

Abstract

The present study is premeditated to extenuate the role of Ficus virens extract and its
bioactive compound on cigarette smoke, an important risk factor for CVD, induced oxidative
stress and hyperlipidemia. Cigarette smoke (CS) exposure to rats results in significant loss of
body weight and increases blood carbon monoxide saturation (carboxyhemoglobin), nicotine,
plasma TC, TG, and LDL-C levels but reduced level of antiatherogenic HDL-C. Moreover,
owing to substantial oxidative stress generated in rats due to cigarette smoke a significant
increase in plasma and erythrocytes lipid peroxidation products were observed which was well
correlated with increase in ex-vivo BDC (48%) and MDA (53%) level (p < 0.001). Simultaneous
administration of FVBM extract at higher dose (100 mg/rat) and F18 (n-Octadecanyl-O-α-Dglucopyranosyl(
6’→1’’)-O-α-D-glucopyranoside) compound to CS-exposed rats effectively
blocked the increase in plasma lipid and lipoprotein levels (p < 0.001) which was due to the
marked suppression in the hepatic HMG-CoA reductase activity (p < 0.001) and significantly
inhibit the lipid peroxidation process thus preventing the membrane damage, LDL oxidation,
and in turn subsequent atherosclerosis. Thus, the results clearly demonstrated the protective
role of FVBM extract and F18 compound in risk factor induced cardiovascular disease.

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